Weslaco Hotel Offers Quality Service, Ideal Location Welcome to the Holiday Inn Express® hotel in Weslaco, Texas. Our comfortable hotel is conveniently located in the heart of the Rio Grande Valley, making us the perfect choice for all travelers. If you are visiting the area for business, our hotel has exactly what you need. We are situated near many local businesses like Knapp Medical Center, Woodcrafters and South Texas College. Additionally, the USDA Subtropical Research Center and Texas A&M Research Center are located just across the street. We know staying connected is important, so we offer free high-speed Internet access and a business center. Our Weslaco, Texas hotel's location is only moments away from the region's best attractions. Leisure travelers appreciate our close proximity to attractions like the Rio Grande Valley Premium Outlets, the World Birding Center at Estero Llano Grande State Park and the Rio Grande Valley Livestock Show. Guests can also explore the quaint border town of Nuevo Progresso, Mexico, located less than 10 miles from our hotel in Weslaco. During your stay, be sure to take advantage our hotel's many amenities and services. We have a heated outdoor pool, well-equipped fitness center and a complimentary, hot breakfast bar. Whatever the reason for your trip to Weslaco, Texas our hotel's convenient location, top-notch amenities and friendly service ensure a carefree stay. Make your reservations today!