Enjoy One of the Best Madison, Indiana Hotels Minutes away from the Ohio River, Madison is a small Indiana town with lots of character. Halfway between Cincinnati, Ohio and Louisville, Kentucky, it's also the perfect place for a weekend getaway or a business venture. The Holiday Inn Express® Hotel Madison is near many local companies such as Rotary Lift, Madison Precision, Grote Industries, Meese Orbitron Dunn and Century Tube. Our hotel in Madison, IN is also five miles from Hanover College. You can host a small meeting in our boardroom or use our 24-hour Business Center. Want to relax and have fun in Madison, IN? Our hotel is close to attractions like Belterra Casino, historic homes like the Lanier Mansion and the Saddletree Factory Museum. You can also enjoy a round of golf near our hotel in Madison, IN, as well as hike through Clifty Falls State Park or sample wines throughout Indiana wine country. For high-powered adventure, watch hydroplane boats participate in the Madison Regatta, which attracts thousands of people to Madison, Indiana. Our hotel's fantastic amenities are easy to enjoy no matter what brings you to town. We're sure you'll enjoy a dip in our indoor pool, an invigorating workout in our Fitness Center and a delicious breakfast every morning at our complimentary, hot Express Start breakfast bar. Make your reservations today to enjoy everything our terrific Madison, IN hotel has to offer you!