Festus, MO Hotel's Guests are Close to St. Louis Thanks to a convenient location off I-55 at exit 175 and just 30 minutes from downtown St. Louis, the Holiday Inn Express® & Suites Festus - South St. Louis hotel's guests are close to everything.When business brings you to South St. Louis and Festus, our 100% smoke-free hotel is the smart choice. Shorter commutes to Saint Grobain, Holcim, Buzzi and River Cement make your day easier. A 24-hour Business Center, free high-speed, Wi-Fi access and a meeting room that can seat 25 keep you productive while you travel. Families on vacation love the convenience of this location in Festus and South St. Louis. Our hotel's friendly staff can offer terrific suggestions on what to see and do. Spend the day sampling Missouri wines, or head into St. Louis to visit the iconic Gateway Arch. Sports fans can catch the Rams, Cardinals or the Blues in action. From the historic Anheuser estate to a visit to the brewery, there's no shortage of things to enjoy while you're in Festus. Our contemporary hotel welcomes you with all the modern amenities you've come to expect. From spacious rooms with a 32-inch LCD TV to the complimentary, hot Express Start Breakfast Bar, we know what you want. You can relax year-round in the indoor pool or work out in the nicely equipped Fitness Center. See for yourself why guests love our service, and book your reservation for a memorable stay in Festus, MO as our hotel's guest!